#4 Eyecare's Lit - Rewiring Dry Eyes: Nasal Spray Boosts Tears in Sjögren’s Artwork

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#4 Eyecare's Lit - Rewiring Dry Eyes: Nasal Spray Boosts Tears in Sjögren’s

December 10, 2025 • Dr. Dave Kading & Dr. Mile Brujic

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Rewiring Dry Eyes: Nasal Spray Boosts Tears in Sjögren’s
In this episode, we unpack a 2025 pilot study from the University of Pennsylvania that tested varenicline nasal spray for dry eye disease in Sjögren’s patients. Learn how neural stimulation through the nose improved tear production, reduced inflammation, and offered new hope for one of ophthalmology’s most challenging autoimmune conditions.

Source: Gupta AS et al., Clinical Ophthalmology. 2025;19:1073–1084. DOI: 10.2147/OPTH.S512364.

LINK: Varenicline solution nasal spray for the treatment of dry eye disease | OPTH